AD  - Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
TA  - J Vet Med Sci
LR  - 20041117
DCOM- 20040326
PST - ppublish
AB  - Three dogs clinically diagnosed with allergic rhinitis (AR) were examined for their immunological findings. House dust mites (HDM) such as Dermatophagoides farinae (DF) and D. pteronyssinus (DP) were identified as positive allergens in the 3 dogs with both intradermal skin test and serum antigen-specific IgE test. Lymphocyte blastogenic response of peripheral blood mononuclear cells (PBMCs) under stimulation with DF antigen in dogs with AR was higher than that in 4 healthy control dogs. Expression level of IL-4 mRNA in PBMCs obtained from the 3 AR dogs was higher than that in PBMCs obtained from 4 healthy control dogs before and after stimulation with DF antigen. Expression level of IFN-gamma mRNA in PBMCs was not different between the AR and control dogs before and after stimulation with DF antigen. These results suggested that allergic reaction to HDM antigen and T(H)2-type immune response were associated with the development of AR in 3 dogs examined in this study.
STAT- MEDLINE
RN  - 0 (Cytokines)
RN  - 0 (DNA Primers)
RN  - 0 (Histamine Antagonists)
RN  - 0 (RNA, Messenger)
RN  - 50-24-8 (Prednisolone)
RN  - 82115-62-6 (Interferon Type II)
LA  - eng
PG  - 25-9
SB  - IM
DA  - 20040212
IP  - 1
EDAT- 2004/02/13 05:00
AU  - Kurata K
AU  - Maeda S
AU  - Yasunaga S
AU  - Masuda K
AU  - Sakaguchi M
AU  - Ohno K
AU  - Tsujimoto H
JID - 9105360
OWN - NLM
MHDA- 2004/03/27 05:00
PMID- 14960806
SO  - J Vet Med Sci. 2004 Jan;66(1):25-9.
DP  - 2004 Jan
IS  - 0916-7250 (Print)
TI  - Immunological findings in 3 dogs clinically diagnosed with allergic rhinitis.
FAU - Kurata, Keigo
FAU - Maeda, Sadatoshi
FAU - Yasunaga, Sho
FAU - Masuda, Kenichi
FAU - Sakaguchi, Masahiro
FAU - Ohno, Koichi
FAU - Tsujimoto, Hajime
MH  - Animals
MH  - Base Sequence
MH  - Cytokines/genetics
MH  - DNA Primers
MH  - Dog Diseases/drug therapy/*immunology
MH  - Dogs
MH  - Histamine Antagonists/therapeutic use
MH  - Interferon Type II/genetics
MH  - Prednisolone/therapeutic use
MH  - RNA, Messenger/genetics
MH  - Research Support, Non-U.S. Gov't
MH  - Rhinitis, Allergic, Perennial/drug therapy/immunology/*veterinary
PL  - Japan
VI  - 66
PT  - Journal Article