Toxicol Sci 2003 Jul;74(1):139-46. Epub 2003 May 28.
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Comparing the effects of stage and duration of retinoic Acid exposure on amphibian limb development: chronic exposure results in mortality, not limb malformations.
Degitz SJ, Holcombe GW, Kosian PA, Tietge JE, Durhan EJ, Ankley GT
U.S. Environmental Protection Agency, Mid-Continent Ecology Division, 6201 Congdon Boulevard, Duluth, Minnesota 55804, USA.
Article type: Curated - Canary ID: 1657
| Cause and Effect Analysis |
Interspecies susceptibility data |
Shared exposures with humans |
Shared outcomes with humans |
Gene sequence data |
| Yes |
No |
No |
No |
No |
| Study type |
N |
Routes |
Sampling |
Controls |
Timing |
| experimental |
600 |
ingestion, other, mucocutaneous |
- |
- |
- |
| Exposures |
Tretinoin
|
| Outcomes |
Anophthalmos
Craniofacial Abnormalities
Edema
embryonic development <1>
Growth
Holoprosencephaly
Metamorphosis, Biological
Mortality
|
| Species |
Xenopus laevis
|
|
