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Center for One Health Research
University of Washington




Toxicol Sci 2003 Jul;74(1):139-46. Epub 2003 May 28.

Comparing the effects of stage and duration of retinoic Acid exposure on amphibian limb development: chronic exposure results in mortality, not limb malformations.

Degitz SJ, Holcombe GW, Kosian PA, Tietge JE, Durhan EJ, Ankley GT

U.S. Environmental Protection Agency, Mid-Continent Ecology Division, 6201 Congdon Boulevard, Duluth, Minnesota 55804, USA.

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Article type: Curated - Canary ID: 1657

Cause and Effect Analysis Interspecies susceptibility data Shared exposures with humans Shared outcomes with humans Gene sequence data
Yes No No No No
Study type N Routes Sampling Controls Timing
experimental 600 ingestion, other, mucocutaneous - - -
Exposures Tretinoin
Outcomes Anophthalmos
Craniofacial Abnormalities
Edema
embryonic development <1>
Growth
Holoprosencephaly
Metamorphosis, Biological
Mortality
Species Xenopus laevis

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