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Center for One Health Research
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Toxicol Sci 2000 Oct;57(2):264-74.

Stage- and species-specific developmental toxicity of all-trans retinoic acid in four native North American ranids and Xenopus laevis.

Degitz SJ, Kosian PA, Makynen EA, Jensen KM, Ankley GT

U.S. Environmental Protection Agency, Mid-Continent Ecology Division, 6201 Congdon Boulevard, Duluth, Minnesota 55804, USA. [email protected]

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Article type: Curated - Canary ID: 1654

Cause and Effect Analysis Interspecies susceptibility data Shared exposures with humans Shared outcomes with humans Gene sequence data
Yes Yes No No No
Study type N Routes Sampling Controls Timing
experimental 210 ingestion, other - - -
Exposures Vitamin A
Risk factors Species Specificity
Outcomes Abnormalities, Multiple
Anophthalmos
Holoprosencephaly
Lethal Dose 50
Limb Deformities, Congenital
Mortality
Survival
toxicity <1>
Species Rana clamitans
Rana pipiens
Rana septentrionalis
Wood frog
Xenopus laevis

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